ABSTRACT
Chronic hepatitis C infection is an important cause of cirrhosis and hepatocellular carcinoma (HCC). Antiviral therapy (AVT) for patients with cirrhosis due to hepatitis C may retard the progression of cirrhosis and prevent both the development of HCC as well as the recurrence of hepatitis C following liver transplantation. This review highlights the issues associated with AVT for patients with compensated and decompensated cirrhosis due to hepatitis C virus.
Subject(s)
Humans , Antiviral Agents , Therapeutic Uses , Carcinoma, Hepatocellular , Virology , Disease Progression , Hepacivirus , Hepatitis C, Chronic , Drug Therapy , Liver Cirrhosis , Drug Therapy , Virology , Liver Neoplasms , Virology , Liver Transplantation , Secondary PreventionABSTRACT
Current guidelines recommend screening cirrhotic patients with an endoscopy to detect esophageal varices and to institute prophylactic measures in patients with large esophageal varices. In this study, we aimed at identifying non-endoscopic parameters that could predict the presence and grades of esophageal varices. In a prospective study, 229 newly diagnosed patients with liver cirrhosis, without a history of variceal bleeding, were included. Demographic, clinical, biochemical and ultrasonographic parameters were recorded. Esophageal varices were classified as small and large, at endoscopy. Univariate analysis and multivariate logistic regression analysis were done to identify independent predictors for the presence and grades of varices. Of the 229 patients [141 males; median age 42 years; range 17-73 years] with liver cirrhosis, 97 [42.3%] had small and 81 [35.4%] had large varices. On multivariate analysis, low platelet count [Odd's Ratio [OR], 4.3; 95% confidence interval [CI], 1.2-14.9], Child Pugh class B/C [OR, 3.3; 95% CI, 1.8-6.3], spleen diameter [OR, 4.3; 95% CI, 1.6-11.9] and portal vein diameter [OR, 2.4; 95% CI, 1.1-5.3] were independent predictors for the presence of varices. Likewise, for the presence of large esophageal varices, low platelet count [OR, 2.7; 95% CI, 1.4-5.2], Child Pugh class B/C [OR, 3.8; 95% CI, 2.3-6.5] and spleen diameter [OR, 3.1; 95% CI, 1.6-6.0] were the independent risk factors. The presence and higher grades of varices can be predicted by a low platelet count, Child-Pugh class B/C and spleen diameter. These may be considered as non-endoscopic predictors for the diagnosis and management of large grade varices